Abstract
The article examines the United States’ engagement with Central Asian countries through the C5+1 initiative, highlighting its evolution, challenges, and strategic implications. Central Asia's significant geostrategic position and history have made it a focal point for global powers. The C5+1 initiative, encompassing the U.S. and five Central Asian nations, represents a strategic realignment of U.S. policies in the region post-9/11. This initiative aims to balance the dominant Russian influence and China’s growing economic power. The article explores how the C5+1 initiative has established foundational frameworks for cooperation, addressing a range of issues from economic development to security concerns. The analysis underscores the initiative's role in shaping U.S. foreign policy towards Central Asia, considering regional dynamics and international relations.